1,176 research outputs found
Detecting the Stimulated Decay of Axions at Radio Frequencies
Assuming axion-like particles account for the entirety of the dark matter in
the Universe, we study the possibility of detecting their decay into photons at
radio frequencies. We discuss different astrophysical targets, such as dwarf
spheroidal galaxies, the Galactic Center and halo, and galaxy clusters. The
presence of an ambient radiation field leads to a stimulated enhancement of the
decay rate; depending on the environment and the mass of the axion, the effect
of stimulated emission may amplify the photon flux by serval orders of
magnitude. For axion-photon couplings allowed by astrophysical and laboratory
constraints(and possibly favored by stellar cooling), we find the signal to be
within the reach of next-generation radio telescopes such as the Square
Kilometer Array.Comment: Minor changes, references added, matches published versio
Control Infrastructure for a Pulsed Ion Accelerator
We report on updates to the accelerator controls for the Neutralized Drift
Compression Experiment II, a pulsed induction-type accelerator for heavy ions.
The control infrastructure is built around a LabVIEW interface combined with an
Apache Cassandra backend for data archiving. Recent upgrades added the storing
and retrieving of device settings into the database, as well as ZeroMQ as a
message broker that replaces LabVIEW's shared variables. Converting to ZeroMQ
also allows easy access via other programming languages, such as Python
Distinct metabolic programs induced by TGF-β1 and BMP2 in human articular chondrocytes with osteoarthritis
Objectives: Cellular energy metabolism is important for the function of all tissues, including cartilage. Recent studies indicate that superficial and deep subpopulations of articular chondrocytes (ACs) have distinct metabolic profiles. At the cellular and molecular level, osteoarthritis (OA) is characterised by alteration from a healthy homoeostatic state towards a catabolic state. Several molecular pathways, including transforming growth factor beta (TGF-β) and bone morphogenetic protein (BMP) signalling, have been identified as critical players in the pathogenesis and progression of OA. However, the manner in which these factors influence cellular energy metabolism in ACs is not well understood. This study investigates the effect of TGF-β or BMP signalling on energy metabolism in human articular chondrocytes (hACs).
Methods: ACs were isolated from residual macroscopically full thickness and intact cartilage from the femoral condyle of human samples obtained from patients with OA. ACs were treated with Vehicle (control), TGF-β1 or BMP2 for 48â72 hours. Metabolic assays were performed to determine glucose consumption, lactate production and adenosine triphosphate (ATP) production, whereas the mitochondrial stress test was performed to determine oxygen consumption rate. Protein was isolated to assess translational activity and was evaluated using Western blot.
Results: We showed that TGF-β1, known to maintain chondrocyte homoeostasis, stimulated glycolysis by upregulating key glycolytic factors, such as glucose transporter 1 (Glut1) and hexokinase II, while reducing oxidative phosphorylation in hACs. In contrast, BMP2 enhanced mitochondrial metabolism and oxidative phosphorylation and had a minimal effect on key glycolytic regulators.
Conclusions: Our data revealed distinct metabolic programs induced by TGF-β1 and BMP2 in hACs, suggesting that the regulation of cellular metabolism may represent a new mechanism underlying the pathogenesis of OA.
The translational potential of this article: The findings define the regulation of energy metabolism as a potential novel therapeutic approach for the treatment of OA
Local Group dSph radio survey with ATCA (III): Constraints on Particle Dark Matter
We performed a deep search for radio synchrotron emissions induced by weakly
interacting massive particles (WIMPs) annihilation or decay in six dwarf
spheroidal (dSph) galaxies of the Local Group. Observations were conducted with
the Australia Telescope Compact Array (ATCA) at 16 cm wavelength, with an rms
sensitivity better than 0.05 mJy/beam in each field. In this work, we first
discuss the uncertainties associated with the modeling of the expected signal,
such as the shape of the dark matter (DM) profile and the dSph magnetic
properties. We then investigate the possibility that point-sources detected in
the proximity of the dSph optical center might be due to the emission from a DM
cuspy profile. No evidence for an extended emission over a size of few arcmin
(which is the DM halo size) has been detected. We present the associated bounds
on the WIMP parameter space for different annihilation/decay final states and
for different astrophysical assumptions. If the confinement of electrons and
positrons in the dSph is such that the majority of their power is radiated
within the dSph region, we obtain constraints on the WIMP annihilation rate
which are well below the thermal value for masses up to few TeV. On the other
hand, for conservative assumptions on the dSph magnetic properties, the bounds
can be dramatically relaxed. We show however that, within the next 10 years and
regardless of the astrophysical assumptions, it will be possible to
progressively close in on the full parameter space of WIMPs by searching for
radio signals in dSphs with SKA and its precursors.Comment: 17 pages, 6 figure panels. Companion papers: arXiv:1407.5479 and
arXiv:1407.5482. v3: minor revision, matches published versio
Multiple Metamorphic Stages within an Eclogite-facies Terrane (Sesia Zone, Western Alps) Revealed by Th-U-Pb Petrochronology
Convergent plate margins typically experience a transition from subduction to collision dynamics as massive continental blocks enter the subduction channel. Studies of high-pressure rocks indicate that tectonic fragments are rapidly exhumed from eclogite facies to mid-crustal levels, but the details of such dynamics are controversial. To understand the dynamics of a subduction channel we report the results of a petrochronological study from the central Sesia Zone, a key element of the internal Western Alps. This comprises two polymetamorphic basement complexes (Eclogitic Micaschist Complex and Gneiss Minuti Complex) and a thin, dismembered cover sequence (Scalaro Unit) associated with pre-Alpine metagabbros and metasediments (Bonze Unit). Structurally controlled samples from three of these units (Eclogitic Micaschist Complex and Scalaro-Bonze Units) yield unequivocal petrological and geochronological evidence of two distinct high-pressure stages. Ages (U-Th-Pb) of growth zones in accessory allanite and zircon, combined with inclusion and textural relationships, can be tied to the multi-stage evolution of single samples. Two independent tectono-metamorphic âslices' showing a coherent metamorphic evolution during a given time interval have been recognized: the Fondo slice (which includes Scalaro and Bonze rocks) and the Druer slice (belonging to the Eclogitic Micaschist Complex). The new data indicate separate stages of deformation at eclogite-facies conditions for each recognized independent kilometer-sized tectono-metamorphic slice, between âź85 and 60 Ma, with evidence of intermittent decompression (ÎP âź 0¡5 GPa) within only the Fondo slice. The evolution path of the Druer slice indicates a different P-T-time evolution with prolonged eclogite-facies metamorphism between âź85 and 75 Ma. Our approach, combining structural, petrological and geochronological techniques, yields field-based constraints on the duration and rates of dynamics within a subduction channe
The Isotropic Radio Background and Annihilating Dark Matter
Observations by ARCADE-2 and other telescopes sensitive to low frequency
radiation have revealed the presence of an isotropic radio background with a
hard spectral index. The intensity of this observed background is found to
exceed the flux predicted from astrophysical sources by a factor of
approximately 5-6. In this article, we consider the possibility that
annihilating dark matter particles provide the primary contribution to the
observed isotropic radio background through the emission of synchrotron
radiation from electron and positron annihilation products. For reasonable
estimates of the magnetic fields present in clusters and galaxies, we find that
dark matter could potentially account for the observed radio excess, but only
if it annihilates mostly to electrons and/or muons, and only if it possesses a
mass in the range of approximately 5-50 GeV. For such models, the annihilation
cross section required to normalize the synchrotron signal to the observed
excess is sigma v ~ (0.4-30) x 10^-26 cm^3/s, similar to the value predicted
for a simple thermal relic (sigma v ~ 3 x 10^-26 cm^3/s). We find that in any
scenario in which dark matter annihilations are responsible for the observed
excess radio emission, a significant fraction of the isotropic gamma ray
background observed by Fermi must result from dark matter as well.Comment: 11 pages, 6 figure
VLBA determination of the distance to nearby star-forming regions I. The distance to T Tauri with 0.4% accuracy
In this article, we present the results of a series of twelve 3.6-cm radio
continuum observations of T Tau Sb, one of the companions of the famous young
stellar object T Tauri. The data were collected roughly every two months
between September 2003 and July 2005 with the Very Long Baseline Array (VLBA).
Thanks to the remarkably accurate astrometry delivered by the VLBA, the
absolute position of T Tau Sb could be measured with a precision typically
better than about 100 micro-arcseconds at each of the twelve observed epochs.
The trajectory of T Tau Sb on the plane of the sky could, therefore, be traced
very precisely, and modeled as the superposition of the trigonometric parallax
of the source and an accelerated proper motion. The best fit yields a distance
to T Tau Sb of 147.6 +/- 0.6 pc. The observed positions of T Tau Sb are in good
agreement with recent infrared measurements, but seem to favor a somewhat
longer orbital period than that recently reported by Duchene et al. (2006) for
the T Tau Sa/T Tau Sb system.Comment: 24 pages, 3 pages, AASTEX format, accepted for publication in Ap
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